I’m having a similar issue to this thread but the solutions listed there didn’t work for me.
I was trying to get some Amiga games running & Retroarch seemed to hang completely so I rebooted the device. Afterwards, the default hotkeys for opening the menu, quitting, modifying speed etc stopped working in all cores. I’ve used Restore Tasks in the Toolkit to restore both the Retroarch config & the overrides but there’s no difference: none of the hotkeys work.
So far the only solution I’ve found is to reflash, is there another option I’ve missed?